Rapid initiation of nasal saline irrigation: hospitalizations in COVID-19 patients randomized to alkalinization or povidone-iodine compared to a national dataset

8/17 Early treatment study

Baxter et al., medRxiv, doi:10.1101/2021.08.16.21262044 (Preprint)
Rapid initiation of nasal saline irrigation: hospitalizations in COVID-19 patients randomized to alkalinization or povidone-iodine compared to a national dataset

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Small RCT 79 PCR+ patients 55+ comparing pressure-based nasal irrigation with povidone-iodine and sodium bicarbonate, showing improved recovery with povidone-iodine, and 0/37 COVID-19 related hospitalizations for povidone-iodine compared to 1/42 for sodium bicarbonate. NCT04559035.

Baxter et al., 8/17/2021, Randomized Controlled Trial, USA, North America, preprint, 9 authors, this trial compares with another treatment - results may be better when compared to placebo.

risk of hospitalization, 65.3% lower, RR 0.35, p = 1.00, treatment 0 of 37 (0.0%), control 1 of 42 (2.4%), continuity correction due to zero event (with reciprocal of the contrasting arm).

risk of hospitalization/ER, 79.0% lower, RR 0.21, p = 0.50, treatment 0 of 37 (0.0%), control 2 of 42 (4.8%), continuity correction due to zero event (with reciprocal of the contrasting arm).

risk of no recovery, 56.0% lower, RR 0.44, p = 0.03, treatment 6 of 25 (24.0%), control 18 of 33 (54.5%).

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 18 studies All Outcomes

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