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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hospitalization 65% Improvement Relative Risk Hospitalization/ER 79% Recovery 57% Transmission 37% Hospitalization (b) 94% c19pvpi.com/baxter.html Favors povidone-iodine Favors sodium bicar..
17 August 2021 - Early treatment study
Rapid initiation of nasal saline irrigation: hospitalizations in COVID-19 patients randomized to alkalinization or povidone-iodine compared to a national dataset
Baxter et al., medRxiv, doi:10.1101/2021.08.16.21262044 (Preprint)
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Small RCT 79 PCR+ patients 55+ comparing pressure-based nasal irrigation with povidone-iodine and sodium bicarbonate, showing improved recovery with povidone-iodine, and 0/37 COVID-19 related hospitalizations for povidone-iodine compared to 1/42 for sodium bicarbonate. NCT04559035.
risk of hospitalization, 65.3% lower, RR 0.35, p = 1.00, treatment 0 of 37 (0.0%), control 1 of 42 (2.4%), NNT 42, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of hospitalization/ER, 79.0% lower, RR 0.21, p = 0.50, treatment 0 of 37 (0.0%), control 2 of 42 (4.8%), NNT 21, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of no recovery, 56.8% lower, RR 0.43, p = 0.03, treatment 6 of 27 (22.2%), control 18 of 35 (51.4%), NNT 3.4.
risk of transmission, 36.9% lower, RR 0.63, p = 0.51, treatment 4 of 37 (10.8%), control 6 of 35 (17.1%), NNT 16.
risk of hospitalization, 94.1% lower, RR 0.06, p = 0.004, nasal irrigation vs. CDC data.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Baxter et al., 8/17/2021, Randomized Controlled Trial, USA, North America, preprint, 9 authors, average treatment delay 4.0 days, this trial compares with another treatment - results may be better when compared to placebo.
Contact: @AmyBaxterMD.
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