• Statistically significant improvements are seen for mortality, hospitalization, cases, and viral clearance. 7 studies from 7 independent teams in 5 different countries show statistically significant improvements in isolation (5 for the most serious outcome).
• Meta analysis using the most serious outcome reported shows 50% [37‑61%] improvement. Results are similar for Randomized Controlled Trials, similar after exclusions, and similar for peer-reviewed studies. Early treatment is more effective than late treatment.
• Results are robust — in exclusion sensitivity analysis 13 of 16 studies must be excluded to avoid finding statistically significant efficacy in pooled analysis.
• Some studies only test short term viral load after a single application. Excessive use of PVP-I could affect thyroid function.
• While many treatments have some level of efficacy, they do not replace vaccines and other measures to avoid infection. Only 19% of povidone-iodine studies show zero events in the treatment arm. Multiple treatments are typically used in combination, and other treatments may be more effective.
• No treatment, vaccine, or intervention is 100% available and effective for all variants. All practical, effective, and safe means should be used. Denying the efficacy of treatments increases mortality, morbidity, collateral damage, and endemic risk.
• All data to reproduce this paper and sources are in the appendix.
Covid Analysis et al., 8/5/2022, preprint, 1 author.