Statistically significant lower risk is seen for mortality, cases, and viral clearance. 12 studies from 12 independent teams in 10 countries show statistically significant improvements.
Meta analysis using the most serious outcome reported shows 51% [38‑61%] lower risk. Results are similar for Randomized Controlled Trials, higher quality studies, and peer-reviewed studies. Early treatment is more effective than late treatment.
Results are robust — in exclusion sensitivity analysis 16 of 21 studies must be excluded to avoid finding statistically significant efficacy in pooled analysis.
3 RCTs with 424 patients have not reported results (up to 2 years late).
Excessive use of PVP-I could affect thyroid function.
No treatment or intervention is 100% effective. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments may be more effective. Povidone-Iodine may be detrimental to the natural microbiome, raising concern for side effects, especially with prolonged or excessive use.
All data to reproduce this paper and sources are in the appendix. Other meta analyses show significant improvements with povidone-iodine for viral load Hasan, Idrees and viral clearance Hasan.
2 meta analyses show significant improvements with povidone-iodine for viral load
Hasan,
Idrees and
viral clearance
Hasan.
Covid Analysis et al., Apr 2024, preprint, 1 author.
