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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Decrease in log viral .. 34% Improvement Relative Risk c19pvpi.com/ferrer2.html Favors povidone-iodine Favors control
22 December 2021 - Late treatment study
Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2
Ferrer et al., Scientific Reports, doi:10.1038/s41598-021-03461-y (Peer Reviewed)
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Small very late (>50% 7+ days from symptom onset, 9 PVP-I patients) RCT testing mouthwashing with cetylpyridinium chloride, chlorhexidine, povidone-iodine, hydrogen peroxide, and distilled water, showing no significant differences. Over 30% of patients show >90% decrease in viral load @2 hrs with all 5. Authors note that a trend was observed for viral load decrease with PVP-I @2h for patients <6 days from onset (p=0.06, Wilcox test).
relative decrease in log viral load, 34.0% better, RR 0.66, p = 0.82, treatment 9, control 12, calculated from Supplementary Table 1.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Ferrer et al., 12/22/2021, Randomized Controlled Trial, Spain, Europe, peer-reviewed, 19 authors.
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