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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Virological cure 86% Improvement Relative Risk c19pvpi.com/mohamed.html Favors povidone-iodine Favors control
9 September 2020 - Early treatment study
Early viral clearance among COVID-19 patients when gargling with povidone-iodine and essential oils: a pilot clinical trial
Mohamed et al., medRxiv, doi:10.1101/2020.09.07.20180448 (Preprint)
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Tiny RCT with 5 PVP-I patients, gargling 30 seconds, 3x per day, and 5 control patients (essential oils and tap water were also tested), showing improved viral clearance with PVP-I.
risk of no virological cure, 85.7% lower, RR 0.14, p = 0.17, treatment 0 of 5 (0.0%), control 3 of 5 (60.0%), NNT 1.7, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 12.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Mohamed et al., 9/9/2020, Randomized Controlled Trial, Malaysia, Europe, preprint, 16 authors.
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