Early viral clearance among COVID-19 patients when gargling with povidone-iodine and essential oils: a pilot clinical trial

9/9 Early treatment study

Mohamed et al., medRxiv, doi:10.1101/2020.09.07.20180448 (Preprint)
Early viral clearance among COVID-19 patients when gargling with povidone-iodine and essential oils: a pilot clinical trial

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Tiny RCT with 5 PVP-I patients, gargling 30 seconds, 3x per day, and 5 control patients (essential oils and tap water were also tested), showing improved viral clearance with PVP-I.

Mohamed et al., 9/9/2020, Randomized Controlled Trial, Malaysia, Europe, preprint, 16 authors.

risk of no virological cure, 85.7% lower, RR 0.14, p = 0.17, treatment 0 of 5 (0.0%), control 3 of 5 (60.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), day 12.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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