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PVP-I study #15   Meta Analysis
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Inverse relative impro.. 89% Imp. Relative Risk, 95% CI Elzein: In vivo evaluation of the virucidal efficacy of chlorhex.. c19pvpi.com/elzein.html Favors povidone-iodine Favors control
3/17 Early treatment study
Elzein et al., Journal of Evidence Based Dental Practice, doi:10.1016/j.jebdp.2021.101584 (preprint 3/17) (Peer Reviewed)
In vivo evaluation of the virucidal efficacy of chlorhexidine and povidone-iodine mouthwashes against salivary SARS-CoV-2. A randomized-controlled clinical trial
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Small RCT comparing mouthwashing with PVP-I, Chlorhexidine, and water, showing significant efficacy for both PVP-I and Chlorhexidine, with PVP-I increasing Ct by a mean of 4.45 (p < 0.0001) and Chlorhexidine by a mean of 5.69 (p < 0.0001), compared to no significant difference for water.
inverse relative improvement in Ct value, 88.8% lower, RR 0.11, p < 0.05, treatment 25, control 9.
Elzein et al., 3/17/2021, Double Blind Randomized Controlled Trial, Lebanon, Middle East, peer-reviewed, 7 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical significance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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