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0 0.5 1 1.5 2+ Viral load, 3m left 33% Improvement Relative Risk Viral load, 3m right 88% Viral load, 4h right 83% c19pvpi.com Sirijatuphat et al. TCTR20210125002 Povidone-Iod.. EARLY Favors povidone-iodine Favors control
Sirijatuphat, 12 patient povidone-iodine early treatment study: 33% improved viral clearance [p=0.58] https://c19p.org/sirijatuphat3
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A pilot study of 0.4% povidone-iodine nasal spray to eradicate SARS-CoV-2 in the nasopharynx
Sirijatuphat et al., medRxiv, doi:10.1101/2022.08.18.22278340 (Preprint), TCTR20210125002
22 Aug 2022    Source   PDF   Share   Tweet
Small single-arm trial testing short-term viral load change after a single administration of three puffs of 0.4% PVP-I, showing lower viral titer at 3 minutes and 4 hours, not reaching statistical significance. Authors note that one reason for the lower change compared to in vitro results is that the spray administration may be less effective.
viral load, 33.3% lower, relative load 0.67, p = 0.58, after median 2560.0 IQR 17790.0 n=12, before median 3840.0 IQR 9600.0 n=12, before values 640.0 640.0 40960.0 2560.0 10240.0 10240.0 640.0 2560.0 10240.0 5120.0 40960.0 640.0, after values 10.0 40.0 2560.0 40960.0 5120.0 1280.0 160.0 2560.0 40960.0 40960.0 10240.0 40.0, relative median viral titer, 3 min, left vs. baseline, Mann-Whitney, Table 3.
viral load, 87.5% lower, relative load 0.12, p = 0.04, after median 480.0 IQR 4340.0 n=12, before median 3840.0 IQR 9600.0 n=12, before values 640.0 640.0 40960.0 2560.0 10240.0 10240.0 640.0 2560.0 10240.0 5120.0 40960.0 640.0, after values 80.0 160.0 10240.0 320.0 320.0 10240.0 40.0 640.0 640.0 40960.0 2560.0 0.0, relative median viral titer, 3 min, right vs. baseline, Mann-Whitney, Table 3.
viral load, 83.3% lower, relative load 0.17, p = 0.11, after median 640.0 IQR 6240.0 n=12, before median 3840.0 IQR 9600.0 n=12, before values 640.0 640.0 40960.0 2560.0 10240.0 10240.0 640.0 2560.0 10240.0 5120.0 40960.0 640.0, after values 160.0 10.0 10240.0 640.0 160.0 1280.0 320.0 640.0 5120.0 40960.0 20480.0 0.0, relative median viral titer, 4 hours, right vs. baseline, Mann-Whitney, Table 3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sirijatuphat et al., 22 Aug 2022, prospective, Thailand, preprint, median age 34.0, 4 authors, study period 15 February, 2021 - 15 March, 2021, trial TCTR20210125002.
Contact: amorn.lee@mahidol.ac.th.
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